Journal article

Biological and Behavioral Factors Associated With Positive Chlamydia Retests

Kirsty S Smith, Rebecca Guy, Jennifer Danielewski, Sepehr N Tabrizi, Christopher K Fairley, Anna M McNulty, William Rawlinson, Marion Saville, Suzanne M Garland, Basil Donovan, John M Kaldor, Jane S Hocking



BACKGROUND: Repeat chlamydia detection after treatment is common, and there is concern that treatment failure may be a cause. METHODS: Within a randomized trial, we established a prospective cohort of 600 participants with anogenital chlamydia diagnoses (200 each of women, heterosexual men, and men who have sex with men [MSM]). Participants were invited for repeat testing at 3 months and to complete a behavioral survey at 4 months. Positive samples were analyzed for organism DNA load and genovar. We estimated repeat chlamydia positivity, reinfection and treatment failure rates, and investigated the biological and behavioral factors associated with a repeat positive test. RESULTS: A total of ..

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Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

The REACT study was funded by National Health and Medical Research Council of Australia program grant 568971. REACT study investigators include: Rebecca Guy, Christopher Fairley, Anna McNulty, Phillip Read, Marcus Chen, Catriona Bradshaw, Handan Wand, Marion Saville, Basil Donovan, John Kaldor, Jane Hocking, Sepehr Tabrizi, Suzanne Garland, William Rawlinson and Kirsty Smith. The authors also thank the participants and staff from Melbourne and Sydney Sexual Health Centres including Glenda Fehler and study nurses: Samantha Blake and Karen Worthington; Sam Phillips, Department of Microbiology and Infectious Diseases, Royal Women's Hospital, Melbourne; Muhammad Shahid Jamil, Kirby Institute, UNSW Australia; Christiana Willenborg, SEALS Microbiology, Prince of Wales Hospital, Sydney; Gillian Phillips and Grace Tan, VCS Pathology, Melbourne.