Journal article

An ovine model of cerebral catheter venography for implantation of an endovascular neural interface

Thomas James Oxley, Nicholas Lachlan Opie, Gil Simon Rind, Kishan Liyanage, Sam Emmanuel John, Stephen Ronayne, Alan James McDonald, Anthony Dornom, Timothy John Haynes Lovell, Peter John Mitchell, Iwan Bennett, Sebastien Bauquier, Leon Norris Warne, Chris Steward, David Bruce Grayden, Patricia Desmond, Stephen M Davis, Terence John O'Brien, Clive N May



OBJECTIVE Neural interface technology may enable the development of novel therapies to treat neurological conditions, including motor prostheses for spinal cord injury. Intracranial neural interfaces currently require a craniotomy to achieve implantation and may result in chronic tissue inflammation. Novel approaches are required that achieve less invasive implantation methods while maintaining high spatial resolution. An endovascular stent electrode array avoids direct brain trauma and is able to record electrocorticography in local cortical tissue from within the venous vasculature. The motor area in sheep runs in a parasagittal plane immediately adjacent to the superior sagittal sinus (SS..

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Awarded by Defense Advanced Research Projects Agency (DARPA) MTO Contract

Awarded by Office of Naval Research (ONR) Global

Awarded by National Health and Medical Research Council of Australia (NHMRC)

Funding Acknowledgements

The research was supported by Defense Advanced Research Projects Agency (DARPA) MTO Contract No. N66001-12-1-4045; the Office of Naval Research (ONR) Global No. N62909-14-1-N020; National Health and Medical Research Council of Australia (NHMRC) Project Grant APP1062532 and Development Grant APP1075117; Defence Health Foundation, Australia (Booster Grant); Defence Science Institute, Australia, grant; and Brain Foundation, Australia, research gift. Dr. Oxley acknowledges the support of the Royal Melbourne Hospital Neuroscience Foundation for the Warren Haynes Fellowship, as well as the Faculty of Medicine, University of Melbourne, for the Leslie Eric Paddle Scholarship in Neurology.