Journal article

Hepatitis A virus cellular receptor 2 (HAVCR2) is decreased with viral infection and regulates pro-labour mediators OA

Stella Liong, Ratana Lim, Gillian Barker, Martha Lappas

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | WILEY | Published : 2017

Abstract

PROBLEM: Intrauterine infection caused by viral infection has been implicated to contribute to preterm birth. Hepatitis A virus cellular receptor 2 (HAVCR2) regulates inflammation in non-gestational tissues in response to viral infection. METHOD OF STUDY: The aims of this study were to determine the effect of: (i) viral dsRNA analogue polyinosinic:polycytidylic acid (poly(I:C)) on HAVCR2 expression; and (ii) HAVCR2 silencing by siRNA (siHAVCR2) in primary amnion and myometrial cells on poly(I:C)-induced inflammation. RESULTS: In human foetal membranes and myometrium, HAVCR2 mRNA and protein expression was decreased when exposed to poly(I:C). Treatment of primary amnion and myometrial cells w..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by NHMRC


Funding Acknowledgements

ML is supported by a Career Development Fellowship from the National Health and Medical Research Council (NHMRC; grant no. 1047025). SL is a recipient of the Glyn White Research Fellowship by the Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG) Research Foundation, the Early Career Researcher Fellowship by The University of Melbourne, and the Postdoctoral Award by the Endocrine Society of Australia (ESA). Funding for this study was provided to ML by the NHMRC (grant no. 1058786), Norman Beischer Medical Research Foundation and the Mercy Research Foundation