Journal article

Medication adherence, condom use and sexually transmitted infections in Australian preexposure prophylaxis users

Luxi Lal, Jennifer Audsley, Dean A Murphy, Christopher K Fairley, Mark Stoove, Norm Roth, Richard Moore, Ban K Tee, Nalagafiar Puratmaja, Peter L Anderson, David Leslie, Robert M Grant, John De Wit, Edwina Wright



OBJECTIVE: HIV preexposure prophylaxis (PrEP) decreases risk of HIV acquisition; however, its efficacy is closely dependent on adherence. There is also concern that the preventive effect of PrEP may be offset by risk compensation, notably an increase in condomless anal sex. DESIGN: Multisite, open-label demonstration study that recruited people at current or recent risk of HIV infection in Melbourne, Australia. METHODS: Participants were recruited from three general practice clinics and one sexual health clinic in Melbourne and consented to take daily tenofovir/emtricitabine (TFV/FTC) for 30 months. Sexual practice data, HIV and sexually transmitted infection (STI) test results were collecte..

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Funding Acknowledgements

We thank the participants in the study and the clinical research nursing staff at all sites including Helen Lau, Julie Silvers, Helen Kent, Sian Edwards and Susan Boyd. VicPrEP was funded by the Victorian Department of Health and Human Services and the Alfred Hospital, Melbourne. Gilead Sciences donated the drugs for VicPREP but played no role in the study design, data collection, data analysis or article preparation. VicPrEP Study Team members: E.W., D.M., J.D.W., L.L., J.A., Carol El-Hayek, M.S., Kathy Petoumenos, Andrew Grulich, Iryna Zablotska, P.L.A., Suzanne Crowe, Colin Batrouney, Martin Holt, R.M.G., Marsha Rosengarten, Jude Armishaw, Anna Pierce, Darren Russell, Brent Allan, Alison Duncan, C.K.F., Michelle Giles, Ivette Aguirre, B.K.T., N.R., Timothy Read, R.M. and Jeffrey Willcox.