Cannabis use by women during pregnancy does not influence infant DNA methylation of the dopamine receptor DRD4
Peter D Fransquet, Delyse Hutchinson, Craig A Olsson, Steve Allsop, Elizabeth J Elliott, Lucinda Burns, Richard Mattick, Richard Saffery, Joanne Ryan
AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE | TAYLOR & FRANCIS INC | Published : 2017
BACKGROUND: Maternal cannabis use in pregnancy is linked with long-term adverse behavioral outcomes in offspring. Epigenetic processes established in utero that affect dopaminergic (reward) signaling may mediate risks. Associations between cannabis use and offspring DNA methylation have not been investigated; however, maternal tobacco smoking in pregnancy is associated with distinct patterns of DNA methylation at birth and beyond. OBJECTIVES: To determine whether maternal cannabis use is associated with methylation of the dopamine receptor gene DRD4 promoter in infants. METHODS: Mothers in the Triple B study provided detailed information on drug use in each trimester of pregnancy. Buccal swa..View full abstract
Awarded by Financial Markets Foundation for Children (Australia)
Awarded by Australian National Health and Medical Research Council (NHMRC)
This current study is funded by a grant from the Financial Markets Foundation for Children (Australia) (2015-252). The Triple B study was funded by an Australian National Health and Medical Research Council (NHMRC) Project Grant #GNT630517 for $2,196,179 and was financially supported by the National Drug and Alcohol Research Centre (NDARC), University of New South Wales. NDARC and the National Drug Research Institute (NDRI), Curtin University, are funded by the Australian Government under the Substance Misuse Prevention and Service Improvements Grants Fund. We also acknowledge financial support from Australian Rotary Health and the Foundation for Alcohol Research and Education (FARE).