A Motif and Amino Acid Bias Bioinformatics Pipeline to Identify Hydroxyproline-Rich Glycoproteins
Kim L Johnson, Andrew M Cassin, Andrew Lonsdale, Antony Bacic, Monika S Doblin, Carolyn J Schultz
Plant Physiology | American Society of Plant Biologists | Published : 2017
Intrinsically disordered proteins (IDPs) are functional proteins that lack a well-defined three-dimensional structure. The study of IDPs is a rapidly growing area as the crucial biological functions of more of these proteins are uncovered. In plants, IDPs are implicated in plant stress responses, signaling, and regulatory processes. A superfamily of cell wall proteins, the hydroxyproline-rich glycoproteins (HRGPs), have characteristic features of IDPs. Their protein backbones are rich in the disordering amino acid proline, they contain repeated sequence motifs and extensive posttranslational modifications (glycosylation), and they have been implicated in many biological functions. HRGPs are ..View full abstract
Awarded by Victorian Life Sciences Computation Initiative on its Peak Computing Facility at the University of Melbourne, initiative of the Victorian Government, Australia
Awarded by Australia Research Council Centre of Excellence in Plant Cell Walls - Australian Government's National Collaborative Research Infrastructure Program administered through Bioplatforms Australia
This work was supported by the Victorian Life Sciences Computation Initiative (grant no. VR0191) on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government, Australia; by the 1000 Plants Initiative, which is funded by the Alberta Ministry of Enterprise and Advanced Education, Alberta Innovates Technology Futures, Innovates Centre of Research Excellence, and Musea Ventures; and by the Australia Research Council Centre of Excellence in Plant Cell Walls (grant no. CE1101007 to K.L.J., A.M.C., A.L., M.S.D., and A.B.), which is funded by the Australian Government's National Collaborative Research Infrastructure Program administered through Bioplatforms Australia.