Progastrin: a potential predictive marker of liver metastasis in colorectal cancer
David A Westwood, Oneel Patel, Christopher Christophi, Arthur Shulkes, Graham S Baldwin
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE | SPRINGER | Published : 2017
BACKGROUND AND AIMS: Staging of colorectal cancer often fails to discriminate outcomes of patients with morphologically similar tumours that exhibit different clinical behaviours. Data from several studies suggest that the gastrin family of growth factors potentiates colorectal cancer tumourigenesis. The aim of this study was to investigate whether progastrin expression may predict clinical outcome in colorectal cancer. METHODS: Patients with colorectal adenocarcinoma of identical depth of invasion who had not received neoadjuvant therapy were included. The patients either had stage IIa disease with greater than 3-year disease-free survival without adjuvant therapy or stage IV disease with l..View full abstract
Related Projects (3)
Awarded by National Health and Medical Research Council of Australia
This work was supported in part by grants from the National Health and Medical Research Council of Australia (454322, 1020983, 1062173) and by the award of a Foundation for Surgery Research Scholarship from the Royal Australasian College of Surgeons.