Nasal-associated lymphoid tissues (NALTs) support the recall but not priming of influenza virus-specific cytotoxic T cells
Angela Pizzolla, Zhongfang Wang, Joanna R Groom, Katherine Kedzierska, Andrew G Brooks, Patrick C Reading, Linda M Wakim
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | NATL ACAD SCIENCES | Published : 2017
The lymphoid tissue that drains the upper respiratory tract represents an important induction site for cytotoxic T lymphocyte (CTL) immunity to airborne pathogens and intranasal vaccines. Here, we investigated the role of the nasal-associated lymphoid tissues (NALTs), which are mucosal-associated lymphoid organs embedded in the submucosa of the nasal passage, in the initial priming and recall expansion of CD8+ T cells following an upper respiratory tract infection with a pathogenic influenza virus and immunization with a live attenuated influenza virus vaccine. Whereas NALTs served as the induction site for the recall expansion of memory CD8+ T cells following influenza virus infection or va..View full abstract
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We thank Dr. W. Heath (University of Melbourne) for helpful discussions; Dr. S. Turner (Monash University) for the influenza viruses X31-OVA and PR8-OVA; and Mr. J. Smith for technical assistance. We thank Victor C. Huber (University of South Dakota) and Dr. Paul G. Thomas (St. Jude Children's Research Hospital, Memphis) for the reverse genetics-based plasmids (PA, PB1, and PB2) for live attenuated influenza virus. This work was supported by the National Health and Medical Research Council of Australia. K.K. is a National Health and Medical Research Council Senior Research Fellow Level B. The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health.