Journal article
Asymptomatic Plasmodium vivax infections induce robust IgG responses to multiple blood-stage proteins in a low-transmission region of western Thailand
RJ Longley, CT França, MT White, C Kumpitak, P Sa-Angchai, J Gruszczyk, JB Hostetler, A Yadava, CL King, RM Fairhurst, JC Rayner, WH Tham, W Nguitragool, J Sattabongkot, I Mueller
Malaria Journal | Published : 2017
Abstract
Background: Thailand is aiming to eliminate malaria by the year 2024. Plasmodium vivax has now become the dominant species causing malaria within the country, and a high proportion of infections are asymptomatic. A better understanding of antibody dynamics to P. vivax antigens in a low-transmission setting, where acquired immune responses are poorly characterized, will be pivotal for developing new strategies for elimination, such as improved surveillance methods and vaccines. The objective of this study was to characterize total IgG antibody levels to 11 key P. vivax proteins in a village of western Thailand. Methods: Plasma samples from 546 volunteers enrolled in a cross-sectional survey c..
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Awarded by University of Melbourne
Funding Acknowledgements
The study was funded by the National Institute of Allergy and Infectious Diseases, US (NIH Grant Number 5R01 AI 104822); the Foundation for Innovate New Diagnostics; the Intramural Research Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health; the Malaria Elimination Science Alliance (MESA); the Wellcome Trust (# 098051); and the UK Medical Research Council (MR/J002283/1). IM is supported by a NHMRC Senior Research Fellowship (# 1043345), CTF by the University of Melbourne-Melbourne International Postgraduate Scholarship (MIPS), W-H.T by an Australian Research Council Future Fellowship and WN by a Wellcome Trust Intermediate Fellowship in Public Health and Tropical Medicine (101073/Z/13Z).