Journal article
Whole-genome landscapes of major melanoma subtypes
NK Hayward, JS Wilmott, N Waddell, PA Johansson, MA Field, K Nones, AM Patch, H Kakavand, LB Alexandrov, H Burke, V Jakrot, S Kazakoff, O Holmes, C Leonard, R Sabarinathan, L Mularoni, S Wood, Q Xu, N Waddell, V Tembe Show all
Nature | Published : 2017
DOI: 10.1038/nature22071
Abstract
© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Melanoma of the skin is a common cancer only in Europeans, whereas it arises in internal body surfaces (mucosal sites) and on the hands and feet (acral sites) in people throughout the world. Here we report analysis of whole-genome sequences from cutaneous, acral and mucosal subtypes of melanoma. The heavily mutated landscape of coding and non-coding mutations in cutaneous melanoma resolved novel signatures of mutagenesis attributable to ultraviolet radiation. However, acral and mucosal melanomas were dominated by structural changes and mutation signatures of unknown aetiology, not previously identified in mela..
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Awarded by Horizon 2020 Framework Programme
Funding Acknowledgements
This work was supported by Melanoma Institute Australia, Bioplatforms Australia, the New South Wales Ministry of Health, Cancer Council NSW, National Health and Medical Research Council of Australia (NHMRC), Cancer Institute NSW, Australian Cancer Research Foundation and the National Collaborative Research Infrastructure Strategy. N.K.H., Nicola W., R.A.S., J.S.W. and K.D.-R. were supported by NHMRC Fellowships, K.N. by a Keith Boden Fellowship, G.V.L. by the University of Sydney Medical Foundation, M.S. by Pfizer Australia, the Victorian Endowment for Knowledge, Science and Innovation and NHMRC, L.B.A. by a J. Robert Oppenheimer Fellowship at Los Alamos National Laboratory, and N.L.-B. by the European Research Council (Consolidator Grant 682398). Biobanking was supported by Melanoma Institute Australia, the Victorian Cancer Agency, Victorian Cancer Biobank, Victorian State Government Operational Infrastructure Support Program, Melanoma Research Alliance and the Melbourne Melanoma Project, and the efforts of patients, clinicians and other staff at health services across Australia. Cell lines were provided via the ABN-Oncology group, supported by NHMRC. Research at Los Alamos National Laboratory was under the auspices of the National Nuclear Security Administration of the US Department of Energy; the Los Alamos National Laboratory Institutional Computing Program was supported by contract DE-AC52-06NA25396. We acknowledge the support of colleagues at Melanoma Institute Australia, Royal Prince Alfred Hospital, NSW Health Pathology, Westmead Institute for Medical Research, Peter MacCallum Cancer Centre and Olivia Newton-John Cancer Research Institute. We thank D. Stetner for computing assistance.