Journal article

Risk of stroke from new carotid artery occlusion in the Asymptomatic Carotid Surgery Trial-1.

Anne G den Hartog, Alison W Halliday, Elizabeth Hayter, Hongchao Pan, Xing Kong, Frans L Moll, Gert Jan de Borst, undefined Asymptomatic Carotid Surgery Trial Collaborators

Stroke | Ovid Technologies (Wolters Kluwer Health) | Published : 2013


BACKGROUND AND PURPOSE: In the Asymptomatic Carotid Surgery Trial-1 (ACST-1), 3120 patients with tight asymptomatic carotid stenosis were randomly assigned to medical treatment alone or to carotid endarterectomy and appropriate medication. Successful carotid endarterectomy significantly reduced 10-year stroke risk in younger patients. This study was undertaken to determine the risk of new occlusion and stroke during trial follow-up. METHODS: Patients with contralateral occlusion at trial entry (n=276) or incomplete duplex follow-up (n=137) were excluded. Risk of occlusion and stroke in patients with occlusion was estimated by Kaplan-Meier analysis. Cox proportional hazard regression models w..

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University of Melbourne Researchers