Journal article
Risk of Stroke From New Carotid Artery Occlusion in the Asymptomatic Carotid Surgery Trial-1
Anne G den Hartog, Alison W Halliday, Elizabeth Hayter, Hongchao Pan, Xing Kong, Frans L Moll, Gert Jan de Borst
STROKE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2013
Abstract
BACKGROUND AND PURPOSE: In the Asymptomatic Carotid Surgery Trial-1 (ACST-1), 3120 patients with tight asymptomatic carotid stenosis were randomly assigned to medical treatment alone or to carotid endarterectomy and appropriate medication. Successful carotid endarterectomy significantly reduced 10-year stroke risk in younger patients. This study was undertaken to determine the risk of new occlusion and stroke during trial follow-up. METHODS: Patients with contralateral occlusion at trial entry (n=276) or incomplete duplex follow-up (n=137) were excluded. Risk of occlusion and stroke in patients with occlusion was estimated by Kaplan-Meier analysis. Cox proportional hazard regression models w..
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Awarded by National Institute for Health Research
Funding Acknowledgements
Funding was from the UK Medical Research Council, Stroke Association, and British United Provident Assocation Foundation Randomization and statistical support were provided by the Oxford Clinical Trial Service Unit. Trial committees were reported previously.<SUP>6</SUP> The sponsors had no role in study design, conduct, interpretation, or reporting. All authors agreed on publication and had full access to the data. A.W. Halliday was funded by the Biomedical Research Center at Oxford University (National Institute for Health Research funding).