Journal article
Qualitative cross-cultural exploration of breast symptoms and impacts associated with hormonal treatments for menopausal symptoms to inform the development of new patient-reported measurement tools
L Abraham, L Humphrey, R Arbuckle, L Dennerstein, JA Simon, S Mirkin, N Bonner, S Walmsley, S Tatlock, T Symonds
Maturitas | ELSEVIER IRELAND LTD | Published : 2015
Abstract
To explore cross-cultural experiences of women taking estrogen plus progestin therapies (EPT) and develop a symptom-based electronic diary and impact questionnaire for EPT-related breast symptoms. (1) Concept elicitation interviews were conducted with women in the US (n = 14), Italy (n = 15), Mexico (n = 15) and China (n = 15) to explore breast symptoms associated with EPT. Patients completed the Breast Sensitivity Questionnaire (BSQ) to evaluate understanding and comprehensiveness. (2) Based on concept elicitation, a 6-item eDiary (Breast Pain/Tenderness Daily Diary - BPT-DD) was generated and the BSQ modified forming the 18-item Breast Sensations Impact Questionnaire (BSIQ). (3) The measur..
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Funding Acknowledgements
The study was funded by Pfizer Pharmaceuticals and was conducted by Adelphi Values. Rob Arbuckle, Louise Humphrey, Steven Walmsley, Nicola Bonner and Sophi Tatlock are consultants and employees of Adelphi Values (or were at the time the research was conducted). Lucy Abraham, Tara Symonds and Sebastian Mirkin are employees of Pfizer Pharmaceuticals (or were at the time the research was conducted). Lorraine Dennerstein and James A. Simon were engaged as key opinion leaders to provide clinical insight into the research. Editorial support for the manuscript has been provided by the medical writing team at Adelphi Values.