Journal article

Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students

Katarzyna Lepeta, Mychael V Lourenco, Barbara C Schweitzer, Pamela V Martino Adami, Priyanjalee Banerjee, Silvina Catuara-Solarz, Mario de La Fuente Revenga, Alain Marc Guillem, Mouna Haidar, Omamuyovwi M Ijomone, Bettina Nadorp, Lin Qi, Nirma D Perera, Louise K Refsgaard, Kimberley M Reid, Mariam Sabbar, Arghyadip Sahoo, Natascha Schaefer, Rebecca K Sheean, Anna Suska Show all

JOURNAL OF NEUROCHEMISTRY | WILEY | Published : 2016

Abstract

Synapses are essential components of neurons and allow information to travel coordinately throughout the nervous system to adjust behavior to environmental stimuli and to control body functions, memories, and emotions. Thus, optimal synaptic communication is required for proper brain physiology, and slight perturbations of synapse function can lead to brain disorders. In fact, increasing evidence has demonstrated the relevance of synapse dysfunction as a major determinant of many neurological diseases. This notion has led to the concept of synaptopathies as brain diseases with synapse defects as shared pathogenic features. In this review, which was initiated at the 13th International Society..

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