Adenosine receptor expression in the development of renal fibrosis following ischemic injury

Abstract

Long-term renal allograft survival has not improved despite improvements in short term outcomes. Graft loss is characterized histologically by the development of interstitial fibrosis and tubular atrophy (IFTA). Mechanisms underlying the development of IFTA are multifactorial and include ischemia-reperfusion injury (IRI). Therapeutic options to reduce IFTA include management of immunologic causes, such as rejection, but despite these efforts IFTA can still occur and leads to the inexorable destruction of the transplanted kidney. The adenosine A<>2B<> receptor (A<>2B<>R) has recently been implicated in the development of renal fibrosis. We performed an observational study to examine the mRNA ..