Journal article

FOXP2-Related Speech and Language Disorders

Angela Morgan, Simon E Fisher, Ingrid Scheffer, Michael Hildebrand

NIH Gene Reviews | Published : 2017


Clinical characteristicsAll FOXP2-related speech and language disorders, regardless of the underlying genetic alteration, have a core phenotype: childhood apraxia of speech (CAS), a disorder of speech motor programming or planning that affects the production, sequencing, timing, and stress of sounds, syllables, and words. All individuals with CAS – whether caused by an alteration of FOXP2 or of an unknown cause – have difficulties in automatically and accurately sequencing speech sounds into syllables, syllables into words, and words into sentences with the correct prosody. Additional findings in FOXP2-related speech and language disorders can include oral motor dyspraxia (difficulty plannin..

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Awarded by NLM NIH HHS