Failure of the adipocytokine, resistin, to protect the heart from ischemia-reperfusion injury.
Christopher CT Smith, Shiang Y Lim, Abigail M Wynne, Vivek Sivaraman, Sean M Davidson, Mihaela M Mocanu, Derek J Hausenloy, Derek M Yellon
J Cardiovasc Pharmacol Ther | Published : 2011
Experimental studies have linked the adipocytokines with acute cardioprotection. Whether the adipocytokine, resistin, confers protection is, however, debatable. In the current study, the actions of resistin, administered at reperfusion, were investigated in in vivo and in vitro rodent and in vitro human models of myocardial ischemia-reperfusion (I/R) injury. Resistin did not reduce infarct size in Langendorff-perfused rat hearts or murine hearts perfused in vivo. Resistin also did not protect human atrial muscle subjected to hypoxia-reoxygenation. Although cyclosporin A delayed mitochondrial permeability transition pore (MPTP) opening in murine cardiomyocytes, resistin was ineffective. Weste..View full abstract