Journal article
Mutations I117V and I117M and oseltamivir sensitivity of pandemic (H1N1) 2009 viruses
AC Hurt, SK Leang, DJ Speers, IG Barr, S Maurer-Stroh
Emerging Infectious Diseases | CENTERS DISEASE CONTROL & PREVENTION | Published : 2012
Abstract
Analysis of mutations I117V and I117M in the neuraminidase of influenza A pandemic (H1N1) 2009 viruses showed that I117V confers a mild reduction in oseltamivir sensitivity and has a synergistic effect of further increasing resistance when combined with H275Y. Contrary to recent reports, the I117M mutation does not alter oseltamivir sensitivity.
Grants
Funding Acknowledgements
The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health and Ageing.