In Vitro Generation of Neuraminidase Inhibitor Resistance in A(H5N1) Influenza Viruses

Aeron C Hurt; Jessica K Holien; Ian G Barr

Journal article

In Vitro Generation of Neuraminidase Inhibitor Resistance in A(H5N1) Influenza Viruses

Aeron C Hurt, Jessica K Holien, Ian G Barr

Antimicrobial Agents and Chemotherapy | AMER SOC MICROBIOLOGY | Published : 2009

DOI: 10.1128/AAC.00334-09

University of Melbourne Researchers

Aeron Hurt Author Melbourne School of Population and Global Health

Ian Barr Author Microbiology and Immunology

Related Projects (1)

ASSESSMENT OF DEVELOPMENT OF RESISTANCE TO NEURAMINIDASE INHIBITORS IN A(H5N1) INFLUENZA VIRUSES USING A FERRET MODEL

The neuraminidase (NA) inhibitors are considered the most effective anti-influenza drugs available for both prevention and treatment of infl..

Grants

Awarded by Australian National Health and Medical Research Council

Funding Acknowledgements

This study was supported by Australian National Health and Medical Research Council award 400595. The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health and Ageing.We thank Robert Shaw, WHO Collaborating Centre for Reference and Research on Influenza, Melbourne, Australia, for experimental assistance; Deborah Middleton and Sue Lowther, Australian Animal Health Laboratory, for provision of laboratory space during the virus growth experiments; and Michael Parker, St. Vincent's Institute of Medical Research, for assistance with structural modeling.