Journal article

Adamantane resistance in influenza A(H1) viruses increased in 2007 in South East Asia but decreased in Australia and some other countries

IG Barr, YM Deng, P Iannello, AC Hurt, N Komadina



The adamantanes (amantadine and rimantadine) were the initial antivirals licensed for use against influenza A viruses and have been used in some countries to control seasonal influenza and have also been stockpiled for potential pandemic use. While high rates of resistance have been observed in recent years with A(H3) viruses, the rates of resistance with A(H1) viruses has varied widely. In this study we analysed 281 human influenza A viruses isolated in 2007 that were referred to the WHO Collaborating Centre for Reference and Research in Melbourne, mainly from Australia and the surrounding regions, for evidence of resistance to adamantanes and a subset of these was examined for resistance t..

View full abstract

University of Melbourne Researchers


Funding Acknowledgements

The authors would like to thank the National Influenza Centres and laboratories in Australia, Cambodia, France, New Caledonia, New Zealand, South Africa, Malaysia, Philippines, Macau (SAR), Singapore, the Solomon Islands, South Africa, Taiwan (POC) and Thailand, for providing influenza isolates that were used for analysis in this paper. The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health and Ageing.