Emergence of multidrug resistance in locally-acquired human infections with Salmonella Typhimurium in Australia owing to a new clade harbouring bla(CTX-M-9)

Sarah J Sparham; Jason C Kwong; Mary Valcanis; Marion Easton; Darren J Trott; Torsten Seemann; Timothy P Stinear; Benjamin P Howden

Journal article

Emergence of multidrug resistance in locally-acquired human infections with Salmonella Typhimurium in Australia owing to a new clade harbouring bla(CTX-M-9)

Sarah J Sparham, Jason C Kwong, Mary Valcanis, Marion Easton, Darren J Trott, Torsten Seemann, Timothy P Stinear, Benjamin P Howden

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | ELSEVIER SCIENCE BV | Published : 2017

DOI: 10.1016/j.ijantimicag.2017.02.014

Abstract

Antimicrobial resistance in non-typhoidal Salmonella is a critical problem globally, with the emergence of resistance to third-generation cephalosporins (3GCs) a particular concern. The aim of this study was to use whole-genome sequencing (WGS) to characterise recently identified human and non-human isolates of 3GC-resistant Salmonella enterica subsp. enterica serovar Typhimurium from Australia. The Illumina NextSeq sequencing platform was used to determine the genome sequences of 78 S. Typhimurium definitive type 44 isolated in Australia between 1992 and 2016, including 31 3GC-resistant isolates. Phylogenetic and bioinformatics analyses were subsequently performed using a number of in silic..

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University of Melbourne Researchers

Torsten Seemann Author Microbiology and Immunology

Ben Howden Author Microbiology and Immunology

Jason Kwong Author Medicine - Austin Health

Tim Stinear Author Microbiology and Immunology

Marion Easton Author Microbiology and Immunology

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Grants

Awarded by National Health and Medical Research Council, Australia

Awarded by NHMRC Centre of Research Excellence in Emerging Infectious Diseases

Funding Acknowledgements

Doherty Applied Microbial Genomics is supported by the Department of Microbiology and Immunology at The Univer-sity of Melbourne (Parkville, VIC, Australia). The National Health and Medical Research Council, Australia, supported this work through fellowships to JCK [GNT1074824], BPH [GNT1105905] and the NHMRC Centre of Research Excellence in Emerging Infectious Diseases [GTN1102962]. The Microbiological Diagnostic Unit Public Health Laboratory is supported by The Victorian Government, Australia.