Journal article

The lipidome in major depressive disorder: Shared genetic influence for ether-phosphatidylcholines, a plasma-based phenotype related to inflammation, and disease risk

EEM Knowles, K Huynh, PJ Meikle, HHH Goring, RL Olvera, SR Mathias, R Duggirala, L Almasy, J Blangero, JE Curran, DC Glahn

EUROPEAN PSYCHIATRY | CAMBRIDGE UNIV PRESS | Published : 2017

Abstract

BACKGROUND: The lipidome is rapidly garnering interest in the field of psychiatry. Recent studies have implicated lipidomic changes across numerous psychiatric disorders. In particular, there is growing evidence that the concentrations of several classes of lipids are altered in those diagnosed with MDD. However, for lipidomic abnormalities to be considered potential treatment targets for MDD (rather than secondary manifestations of the disease), a shared etiology between lipid concentrations and MDD should be demonstrated. METHODS: In a sample of 567 individuals from 37 extended pedigrees (average size 13.57 people, range=3-80), we used mass spectrometry lipidomic measures to evaluate the g..

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Grants

Awarded by National Institute of Mental Health


Awarded by SOLAR NIMH


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Funding Acknowledgements

Grant sponsor: National Institute of Mental Health; Grant numbers: MH078143, MH078111, MH083824; Grant sponsor: SOLAR NIMH; Grant number: MH059490.