Differential regulation of sphingolipid metabolism in plasma, hippocampus, and cerebral cortex of mice administered sphingolipid modulating agents
Corey Giles, Ryusuke Takechi, Natalie A Mellett, Peter J Meikle, Satvinder Dhaliwal, John C Mamo
JOURNAL OF NEUROCHEMISTRY | WILEY | Published : 2017
Accumulation of ceramide is implicated in mediating the cellular responses to stress and aberrant sphingolipid metabolism is frequently associated with metabolic and neurodegenerative diseases. It is often assumed that (i) peripheral disturbances in sphingolipid concentrations are reflective of processes occurring in the brain, or (ii) circulating sphingolipids directly influence cerebral sphingolipid abundance. In order to address these assumptions, this study explores, in a physiological system, the metabolic pathways regulating sphingolipid metabolism in the brain and plasma of mice. Male C57Bl/6 were maintained on a low fat (control diet) or saturated fat enriched (SFA) diet with, or wit..View full abstract
This study was supported by the National Health and Medical Research Council of Australia. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscripts. The authors declare no conflict of interest.