Journal article

Short term fat feeding rapidly increases plasma insulin but does not result in dyslipidaemia

Benjamin Barzel, Jacquelyn M Weir, Peter J Meikle, Sandra L Burke, James A Armitage, Geoffrey A Head

Frontiers in Physiology | FRONTIERS MEDIA SA | Published : 2014


Although the association between obesity and hypertension is well-known, the underlying mechanism remains elusive. Previously, we have shown that 3 week fat feeding in rabbits produces greater visceral adiposity, hypertension, tachycardia and elevated renal sympathetic nerve activity (RSNA) compared to rabbits on a normal diet. Because hyperinsulinaemia, hyperleptinemia, and dyslipidaemia are independent cardiovascular risk factors associated with hypertension we compared plasma insulin, leptin, and lipid profiles in male New Zealand White rabbits fed a normal fat diet (NFD 4.3% fat, n = 11) or high fat diet (HFD 13.4% fat, n = 13) at days 1, 2, 3 and weeks 1, 2, 3 of the diet. Plasma concen..

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