Journal article
Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight/obesity in humans
KT Tonks, AC Coster, MJ Christopher, R Chaudhuri, A Xu, J Gagnon-Bartsch, DJ Chisholm, DE James, PJ Meikle, JR Greenfield, D Samocha-Bonet
Obesity | WILEY | Published : 2016
DOI: 10.1002/oby.21448
Abstract
Objective Alterations in lipids in muscle and plasma have been documented in insulin-resistant people with obesity. Whether these lipid alterations are a reflection of insulin resistance or obesity remains unclear. Methods Nondiabetic sedentary individuals not treated with lipid-lowering medications were studied (n = 51). Subjects with body mass index (BMI) > 25 kg/m2 (n = 28) were stratified based on median glucose infusion rate during a hyperinsulinemic-euglycemic clamp into insulin-sensitive and insulin-resistant groups (above and below median, obesity/insulin-sensitive and obesity/insulin-resistant, respectively). Lean individuals (n = 23) served as a reference group. Lipidomics was perf..
View full abstractGrants
Funding Acknowledgements
This work was supported by funding from Diabetes Australia Research Trust (Millennium Grant), a St. Vincent's Clinic Foundation Grant, the OIS Program of the Victorian Government, and the Garvan Research Foundation, Australia.