Conference Proceedings
Tapping the Power of Plasma Lipidome to Improve Hypertriglyceridemic Waist as a Predictor of Future Type 2 Diabetes
Manju Mamtani, Peter Meikle, Hemant Kulkarni, Gerard Wong, Jacquelyn Weir, Christopher Barlow, Thomas Dyer, Laura Almasy, Michael Mahaney, Anthony Comuzzie, Ravindranath Duggirala, John Blangero, Joanne Curran
FASEB JOURNAL | FEDERATION AMER SOC EXP BIOL | Published : 2015
Abstract
Hypertriglyceridemic waist is considered a specific predictor of T2D because it combines the predictive value of waist circumference (WC) and serum triglycerides (TG). Our objective was to investigate if the addition of specific triacylglycerol (TAG) lipid species to WC performs better than the combination of WC and TG to predict future T2D in initially diabetes‐free individuals (n=771, 9197 person‐years follow‐up). The participants were from the San Antonio Family Heart Study and the plasma lipidome was quantified using high‐performance liquid chromatography and mass spectrometry. A forward addition approach to optimize the integrated discrimination index (IDI) identified five independent a..
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