Plasma lipidomic analysis predicts non-calcified coronary artery plaque in asymptomatic patients at intermediate risk of coronary artery disease
Andris H Ellims, Gerard Wong, Jacquelyn M Weir, Philip Lew, Peter J Meikle, Andrew J Taylor
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING | OXFORD UNIV PRESS | Published : 2014
AIMS: The optimal management of asymptomatic subjects at intermediate risk of coronary artery disease (CAD) is often uncertain. Re-stratification to a high- or low-risk category may enable optimization of preventative strategies. Coronary computed tomographic angiography (CCTA) enables a minimally invasive assessment of coronary artery plaque quantity and composition. Non-calcified plaque by CCTA is lipid-rich and more vulnerable to rupture and resultant acute coronary syndromes. The purpose of this study was to determine whether novel approaches to CAD risk stratification, such as plasma lipid profiling, may predict non-calcified plaque burden in intermediate risk subjects. METHODS AND RESU..View full abstract
A.H.E. is supported by a combined Heart Foundation of Australia and National Health and Medical Research Council Postgraduate Research Scholarship. P.J.M. is supported by a National Health and Medical Research Council fellowship and project grant. A.J.T. is supported by a National Health and Medical Research Council program grant and the Heart Foundation of Australia project grant. This work was further supported by funding from the OIS Program of the Victorian Government.