Journal article

Plasma Dihydroceramide Species Associate with Waist Circumference in Mexican American Families

Manju Mamtani, Peter J Meikle, Hemant Kulkarni, Jacquelyn M Weir, Christopher K Barlow, Jeremy B Jowett, Claire Bellis, Thomas D Dyer, Laura Almasy, Michael C Mahaney, Ravindranath Duggirala, Anthony G Comuzzie, John Blangero, Joanne E Curran

OBESITY | WILEY | Published : 2014

Abstract

OBJECTIVE: Waist circumference (WC), the clinical marker of central obesity, is gaining popularity as a screening tool for type 2 diabetes (T2D). While there is epidemiologic evidence favoring the WC-T2D association, its biological substantiation is generally weak. Our objective was to determine the independent association of plasma lipid repertoire with WC. METHODS: Samples and data from the San Antonio Family Heart Study of 1208 Mexican Americans from 42 extended families were used. Association of plasma lipidomic profiles with the cross-sectionally assessed WC was determined. Plasma lipidomic profiling entailed liquid chromatography with mass spectrometry. Statistical analyses included mu..

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Awarded by National Center for Research Resources


Awarded by Research Facilities Improvement Program


Awarded by National Center for Research Resources of the National Institutes of Health


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Funding Acknowledgements

This work was supported in part by NIH grants R01 DK082610, R01 DK079169 and 1R01 DK088972. Data collection for the San Antonio Family Heart Study was supported by NIH grant P01 HL045522. The development of the analytical methods and software used in this study was supported by NIH grant R37 MH059490. The AT& T Genomics Computing Center supercomputing facilities used for this work were supported in part by a gift from the AT& T Foundation and with support from the National Center for Research Resources Grant Number S10 RR029392. This investigation was conducted in facilities constructed with support from Research Facilities Improvement Program grants C06 RR013556 and C06 RR017515 from the National Center for Research Resources of the National Institutes of Health. The lipidomic analysis was supported by funding from the National Health and Medical Research Council of Australia and by the OIS Program of the Victorian Government.