Effects of prenatal ethanol exposure on the lungs of postnatal lambs
Foula Sozo, Melissa Vela, Victoria Stokes, Kelly Kenna, Peter J Meikle, Robert De Matteo, David Walker, James Brien, Alan Bocking, Richard Harding
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2011
Prenatal ethanol exposure increases collagen deposition and alters surfactant protein (SP) expression and immune status in lungs of near-term fetal sheep. Our objectives were to determine 1) whether these prenatal effects of repeated gestational ethanol exposure persist after birth and 2) whether surfactant phospholipid composition is altered following prenatal ethanol exposure. Pregnant ewes were chronically catheterized at 90 days of gestational age (DGA) and given a 1-h daily infusion of ethanol (0.75 g/kg, n = 9) or saline (n = 7) from 95 to 135 DGA; ethanol administration ceased after 135 DGA. Lambs were born naturally at full term (146 ± 0.5 DGA). Lung tissue was examined at 9 wk postn..View full abstract
This work was supported by the National Health and Medical Research Council of Australia and the Canadian Institutes of Health Research.