Journal article
Postprandial metabolism of docosapentaenoic acid (DPA, 22:5n-3) and eicosapentaenoic acid (EPA, 20:5n-3) in humans
KM Linderborg, G Kaur, E Miller, PJ Meikle, AE Larsen, JM Weir, A Nuora, CK Barlow, HP Kallio, D Cameron-Smith, AJ Sinclair
Prostaglandins Leukotrienes and Essential Fatty Acids | ELSEVIER SCI LTD | Published : 2013
Abstract
The study of the metabolism of docosapentaenoic acid (DPA, 22:5. n-3) in humans has been limited by the unavailability of pure DPA and the fact that DPA is found in combination with eicosapentaenoic acid (EPA, 20:5. n-3) and docosahexaenoic acid (DHA, 22:6. n-3) in natural products. In this double blind cross over study, pure DPA and EPA were incorporated in meals served to healthy female volunteers. Mass spectrometric methods were used to study the chylomicron lipidomics. Plasma chylomicronemia was significantly reduced after the meal containing DPA compared with the meal containing EPA or olive oil only. Both EPA and DPA were incorporated into chylomicron TAGs, while there was less incorpo..
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Funding Acknowledgements
Dr Andrew Garnham is thanked for medical support and Dr Marissa Caldow for clinical trial support. Equateq Ltd (UK) is acknowledged for the generous provision of the pure supplements. Meat & Livestock Australia and Deakin University Strategic Research Centres for Molecular Medicine, and Chemistry and Biotechnology are acknowledged for their financial support. Osk. Huttunen Foundation and Finnish Food Research Foundation are acknowledged for support to Dr Linderborg. Finally we wish to acknowledge and thank our participants.