Journal article
Lipidomic profiling of chylomicron triacylglycerols in response to high fat meals
MP Bonham, KM Linderborg, A Dordevic, AE Larsen, K Nguo, JM Weir, P Gran, MK Luotonen, PJ Meikle, D Cameron-Smith, HPT Kallio, AJ Sinclair
Lipids | WILEY | Published : 2013
Abstract
Using lipidomic methodologies the impact that meal lipid composition and metabolic syndrome (MetS) exerts on the postprandial chylomicron triacylglycerol (TAG) response was examined. Males (9 control; 11 MetS) participated in a randomised crossover trial ingesting two high fat breakfast meals composed of either dairy-based foods or vegetable oil-based foods. The postprandial lipidomic molecular composition of the TAG in the chylomicron-rich (CM) fraction was analysed with tandem mass spectrometry coupled with liquid chromatography to profile CM TAG species and targeted TAG regioisomers. Postprandial CM TAG concentrations were significantly lower after the dairy-based foods compared with the ..
View full abstractGrants
Funding Acknowledgements
The authors would like to thank Dr Andrew Garnham for his medical support. The authors gratefully acknowledge Cabrini pathologies and Baker IDI for analyses of samples and Thorsten Kasel for his assistance with the clinical trial. Lastly we wish to acknowledge and thank our participants. This project was supported with funding from the Dairy Health and Nutrition Consortium (DHNC). The DHNC is a consortium of Tatura Milk Industries and Bega Cheese, National Foods, Fonterra Australia, Parmalat Australia, Dairy Australia, Geoffrey Gardiner Foundation, Murray Goulburn Co-operative, Warrnambool Cheese and Butter Factory, and Dairy Innovation Australia.