Journal article
Pigment epithelium-derived factor regulates lipid metabolism via adipose triglyceride lipase
ML Borg, ZB Andrews, EJ Duh, R Zechner, PJ Meikle, MJ Watt
Diabetes | AMER DIABETES ASSOC | Published : 2011
DOI: 10.2337/db10-0845
Abstract
OBJECTIVE - Pigment epithelium-derived factor (PEDF) is an adipocyte-secreted factor involved in the development of insulin resistance in obesity. Previous studies have identified PEDF as a regulator of triacylglycerol metabolism in the liver that may act through adipose triglyceride lipase (ATGL). We used ATGL-/- mice to determine the role of PEDF in regulating lipid and glucose metabolism. RESEARCH DESIGN AND METHODS - Recombinant PEDF was administered to ATGL-/- and wild-type mice, and whole-body energy metabolism was studied by indirect calorimetry. Adipose tissue lipolysis and skeletal muscle fatty acid metabolism was determined in isolated tissue preparations. Muscle lipids were assess..
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Funding Acknowledgements
These studies were supported by research grants and a fellowship from the National Health and Medical Research Council (NHMRC) of Australia, the Diabetes Australia Research Trust, the William Buck land Foundation (ANZ Trustees Program), and a Monash Fellowship (to M.J.W.). M.L.B. is an Australian Postgraduate Award holder. E.J.D. has received an RPB Career Development Award and is supported by the Juvenile Diabetes Research Foundation.