Plasma lipidomic profiling in patients with rheumatoid arthritis
Lu Fang, Piyushkumar A Mundra, Fenling Fan, Abby Galvin, Jacquelyn M Weir, Gerard Wong, Jaye Chin-Dusting, Flavia Cicuttini, Peter Meikle, Anthony Michael Dart
METABOLOMICS | SPRINGER | Published : 2016
Introduction: Rheumatoid arthritis (RA) is linked to increased cardiovascular morbidity and mortality, not completely explained by traditional risk factors. Importantly, the increased risk occurs despite lower levels of total and low-density lipoprotein cholesterol. Whilst systemic inflammation may be a factor, it is possible that changes in individual lipid species contribute to the increased cardiovascular risk. Objectives: In the present study, we characterized plasma lipidomic profiles in patients with RA in comparison with healthy controls. Methods: Patients with RA (n = 32) and age- and gender-matched healthy volunteers (n = 84) were recruited. Fasting plasma lipid profiles were measur..View full abstract
We are grateful to the clinic support staff in the Rheumatology Clinic of the Alfred Hospital and the Risk Evaluation Service of Baker IDI Heart and Diabetes Institute for help with the clinical aspects of this study. The study was supported by a National Health and Medical Research Council of Australia (NHMRC) program Grant to AMD and the Operational Infrastructure Support (OIS) Program of the Victorian Government, Australia. AMD is a Senior Principal Research Fellow (586656) and PJM is a NHMRC senior research fellow (1042095).