Journal article

Lipidomic dataset of plasma from patients infected with wild type and nef-deficient HIV-1 strain

Peter Meikle, Hann Low, Melissa J Churchill, Michael Bukrinsky, Dmitri Sviridov

Data in Brief | ELSEVIER SCIENCE BV | Published : 2016

Abstract

Previous in vitro and in vivo studies demonstrated that HIV protein nef plays a key role in impairing cellular and systemic cholesterol metabolism in HIV disease, but clinical support for these findings is lacking. Here we present the data of comparative lipidomic analysis (330 lipid species) of plasma samples from HIV-negative subjects, patients infected with WT HIV-1 strain and patients infected with nef-deficient strain of HIV-1. We determine which effects of HIV on plasma lipidome are explained by the presence of nef. The data can be used to evaluate cardiovascular risk in HIV disease and to assess the role of nef in HIV-induced disturbances in systemic lipid metabolism. The full impact ..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by NIH


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Funding Acknowledgements

This study was supported by grants from the National Health and Medical Research Council of Australia (GNT1019847) and NIH (HL101274) to DS and MB and in part by the Victorian Government's OIS Program. DS and PM are Fellows of the National Health and Medical Research Council of Australia.