Journal article

Evaluation of the lysosome-associated membrane protein LAMP-2 as a marker for lysosomal storage disorders

CT Hua, JJ Hopwood, SR Carlsson, RJ Harris, PJ Meikle

Clinical Chemistry | AMER ASSOC CLINICAL CHEMISTRY | Published : 1998


For many lysosomal storage disorders, presymptomatic detection, before the onset of irreversible pathology, will greatly improve the efficacy of current and proposed therapies. In the absence of a family history, presymptomatic detection can be achieved only by a comprehensive newborn screening program. Recently we reported that the lysosome-associated membrane protein LAMP-1 was increased in the plasma from approximately 70% of individuals with lysosomal storage disorders. Here we report on the evaluation of a second lysosome-associated membrane protein, LAMP-2, as a marker for this group of disorders. The median concentration of LAMP-2 in the plasma of healthy individuals was 1.21 mg/L, fo..

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University of Melbourne Researchers