Journal article

Fibrogenesis in Pediatric Cholestatic Liver Disease: Role of Taurocholate and Hepatocyte-Derived Monocyte Chemotaxis Protein-1 in Hepatic Stellate Cell Recruitment

Grant A Ramm, Ross W Shepherd, Anita C Hoskins, Sonia A Greco, Agnieszka D Ney, Tamara N Pereira, Kim R Bridle, James D Doecke, Peter J Meikle, Bruno Turlin, Peter J Lewindon

HEPATOLOGY | WILEY | Published : 2009

Abstract

UNLABELLED: Cholestatic liver diseases, such as cystic fibrosis (CF) liver disease and biliary atresia, predominate as causes of childhood cirrhosis. Despite diverse etiologies, the stereotypic final pathway involves fibrogenesis where hepatic stellate cells (HSCs) are recruited, producing excess collagen which initiates biliary fibrosis. A possible molecular determinant of this recruitment, monocyte chemotaxis protein-1 (MCP-1), an HSC-responsive chemokine, was investigated in CF liver disease and biliary atresia. The bile-duct-ligated rat and in vitro coculture models of cholestatic liver injury were used to further explore the role of MCP-1 in HSC recruitment and proposed mechanism of ind..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by Royal Children Hospital Foundation, Brisbane, Australia


Awarded by National Institutes of Healh


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Funding Acknowledgements

This work was supported by research grants from the National Health and Medical Research Council (NHMRC) of Australia (Grant No. 290220 to G.A.R., A.J.L., and R.W.S.) the Australian Cystic Fibrosis Research Trust (to G.A.R. and P.J.L.) and the Royal Children Hospital Foundation, Brisbane, Australia (Grant Alas. 913-003. 913-005, 972-011, 972-017 to G.A.R., P.J.L.. and R.W.S.) and in part by the National Institutes of Healh (Grant No. 5U01DK62452 to R.W.S. and G.A.R.). G.A.R. is supported by a Senior Research Fellowship from the NHMRC of Australia (Grant No. 241913).