Conference Proceedings

Immunochemical analysis of CD107a (LAMP-1)

EJ Parkinson-Lawrence, CJ Dean, M Chang, JJ Hopwood, PJ Meikle, DA Brooks

Cellular Immunology | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2005

Abstract

CD107a, also known as the lysosome associated membrane protein-1 (LAMP-1), is expressed largely in the endosome-lysosome membranes of cells, but is also found on the plasma membrane (1-2% of total LAMP-1). LAMP-1 has been implicated in a variety of cellular functions, including cancer metastasis. It has been proposed as a therapeutic agent for some cancers, and is a marker for lysosomal storage disorders and different cell types such as cytotoxic T cells. In light of this diversity of applications, it is important to have well characterized immune-reagents for the detection and quantification of LAMP-1. We have compared a new monoclonal antibody 80280 against LAMP-1 to an existing monoclonal..

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University of Melbourne Researchers