Does expert opinion match the operational definition of the Lupus Low Disease Activity State (LLDAS)? A case-based construct validity study
Vera Golder, Molla Huq, Kate Franklyn, Alicia Calderone, Aisha Lateef, Chak Sing Lau, Alfred Lok Hang Lee, Sandra Teresa V Navarra, Timothy Godfrey, Shereen Oon, Alberta Yik Bun Hoi, Eric Francis Morand, Mandana Nikpour
SEMINARS IN ARTHRITIS AND RHEUMATISM | W B SAUNDERS CO-ELSEVIER INC | Published : 2017
OBJECTIVE: To evaluate the construct validity of the Lupus Low Disease Activity State (LLDAS), a treatment target in systemic lupus erythematosus (SLE). METHODS: Fifty SLE case summaries based on real patients were prepared and assessed independently for meeting the operational definition of LLDAS. Fifty international rheumatologists with expertise in SLE, but with no prior involvement in the LLDAS project, responded to a survey in which they were asked to categorize the disease activity state of each case as remission, low, moderate, or high. Agreement between expert opinion and LLDAS was assessed using Cohen's kappa. RESULTS: Overall agreement between expert opinion and the operational def..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC), Australia
Awarded by NHMRC research fellowship
The Asia-Pacific Lupus Collaboration investigators receive project support funding from GlaxoSmithKline, UCB, and Janssen.Dr. Golder holds a postgraduate scholarship from the National Health and Medical Research Council (NHMRC, APP1093545), Australia. Dr. Nikpour holds an NHMRC research fellowship (APP1071735).