Journal article

Phase II trial of docetaxel in patients with platinum-refractory advanced ovarian cancer.

P Francis, J Schneider, L Hann, C Balmaceda, R Barakat, M Phillips, T Hakes

Journal of Clinical Oncology | Published : 1994

Abstract

PURPOSE: This phase II study was conducted to evaluate the efficacy and toxicity of docetaxel in the treatment of patients with platinum-refractory ovarian cancer. PATIENTS AND METHODS: Twenty-five patients with platinum-refractory advanced ovarian cancer were treated. Twenty of the patients had failed to respond to platinum-based front-line chemotherapy and five had failed to respond to platinum-based therapy repeated at relapse. One patient had received prior pelvic radiation therapy. Patients were required to have bidimensionally measurable disease. Docetaxel was administered at a dose of 100 mg/m2 intravenously (i.v.) over 1 hour every 21 days. Twenty patients received no corticosteroid ..

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