Human t(14;18)positive germinal center B cells: a new step in follicular lymphoma pathogenesis?
Julie Tellier, Cedric Menard, Sandrine Roulland, Nadine Martin, Celine Monvoisin, Lionel Chasson, Bertrand Nadel, Philippe Gaulard, Claudine Schiff, Karin Tarte
BLOOD | AMER SOC HEMATOLOGY | Published : 2014
Follicular lymphoma (FL) is a B-cell neoplasm resulting from the transformation of germinal center (GC) B cells. Although t(14;18) and ectopic B-cell lymphoma 2 (BCL2) expression constitute the genetic hallmark of FL, t(14;18)(pos) B cells bearing genotypic and phenotypic features of FL cells can be found in the blood of most healthy individuals. Nevertheless, the localization of these FL-like cells (FLLCs) in nonmalignant GC-rich tissues and the functional consequences of BCL2 overexpression have not been evaluated thus far. Among 85 reactive lymph node (RLN) samples, 14% were found to contain high levels of t(14;18) by quantitative polymerase chain reaction. In t(14;18)(hi) RLNs, CD20(pos)..View full abstract
Awarded by Institut National du Cancer (INCa libre)
Awarded by Institut National du Cancer (Programmes d'Actions Integrees de Recherche Lymphome)
This work was supported by research grants from the Institut National du Cancer (INCa libre PL06-10 and Programmes d'Actions Integrees de Recherche Lymphome 2008-019), the Ligue Contre le Cancer (Equipe Labellisee 2013), and institutional grants from Institut National de la Sante et de la Recherche Medicale and Centre National de la Recherche Scientifique.