Journal article

Galectin-1-expressing stromal cells constitute a specific niche for pre-BII cell development in mouse bone marrow

Frederic Mourcin, Caroline Breton, Julie Tellier, Priyanka Narang, Lionel Chasson, Audrey Jorquera, Mark Coles, Claudine Schiff, Stephane JC Mancini

BLOOD | AMER SOC HEMATOLOGY | Published : 2011

Abstract

In the bone marrow (BM), stromal cells constitute a supportive tissue indispensable for the generation of pro-B/pre-BI, pre-BII, and immature B lymphocytes. IL-7-producing stromal cells constitute a cellular niche for pro-B/pre-BI cells, but no specific stromal cell microenvironment was identified for pre-BII cells expressing a functional pre-B cell receptor (pre-BCR). However expression of the pre-BCR represents a crucial checkpoint during B-cell development. We recently demonstrated that the stromal cell derived-galectin1 (GAL1) is a ligand for the pre-BCR, involved in the proliferation and differentiation of normal mouse pre-BII cells. Here we show that nonhematopoietic osteoblasts and re..

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University of Melbourne Researchers

Grants

Awarded by Institut National du Cancer


Awarded by Association pour la Recherche contre le Cancer


Awarded by Medical Research Council


Funding Acknowledgements

This work was supported by Institut National du Cancer, Program d'Actions Integrees de Recherche Lymphomes (2008 contract Projet R08008AP), Association pour la Recherche contre le Cancer (contract 1089), Inserm (institutional grants), and CNRS. C. B. was supported by Ministere de l'Education Nationale et de la Recherche and Ligue Contre le Cancer.