Galectin-1-expressing stromal cells constitute a specific niche for pre-BII cell development in mouse bone marrow
Frederic Mourcin, Caroline Breton, Julie Tellier, Priyanka Narang, Lionel Chasson, Audrey Jorquera, Mark Coles, Claudine Schiff, Stephane JC Mancini
BLOOD | AMER SOC HEMATOLOGY | Published : 2011
In the bone marrow (BM), stromal cells constitute a supportive tissue indispensable for the generation of pro-B/pre-BI, pre-BII, and immature B lymphocytes. IL-7-producing stromal cells constitute a cellular niche for pro-B/pre-BI cells, but no specific stromal cell microenvironment was identified for pre-BII cells expressing a functional pre-B cell receptor (pre-BCR). However expression of the pre-BCR represents a crucial checkpoint during B-cell development. We recently demonstrated that the stromal cell derived-galectin1 (GAL1) is a ligand for the pre-BCR, involved in the proliferation and differentiation of normal mouse pre-BII cells. Here we show that nonhematopoietic osteoblasts and re..View full abstract
Awarded by Institut National du Cancer
Awarded by Association pour la Recherche contre le Cancer
Awarded by Medical Research Council
This work was supported by Institut National du Cancer, Program d'Actions Integrees de Recherche Lymphomes (2008 contract Projet R08008AP), Association pour la Recherche contre le Cancer (contract 1089), Inserm (institutional grants), and CNRS. C. B. was supported by Ministere de l'Education Nationale et de la Recherche and Ligue Contre le Cancer.