Journal article

Defined blocks in terminal plasma cell differentiation of common variable immunodeficiency patients.

Nadine Taubenheim, Marcus von Hornung, Anne Durandy, Klaus Warnatz, Lynn Corcoran, Hans-Hartmut Peter, Hermann Eibel

J Immunol | Published : 2005

Abstract

Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by defective Ab production and recurrent bacterial infections. The largely unknown causes are likely to comprise a diverse set of genetic or acquired defects. In this study, we investigated terminal B cell differentiation in lymph nodes from CVID patients. Up to the germinal center B cell stage, B cell differentiation was normal but terminal plasma cell development was found to be impaired. Using differential Blimp-1 and Syndecan-1 expression in controls, we defined three different plasma cell subsets that correspond to progressive developmental stages locating to different sites in the lymph node. In the CVID ..

View full abstract

University of Melbourne Researchers