Journal article

The lymphoid past of mouse plasmacytoid cells and thymic dendritic cells.

Lynn Corcoran, Isabel Ferrero, David Vremec, Karen Lucas, Jason Waithman, Meredith O'Keeffe, Li Wu, Anne Wilson, Ken Shortman

J Immunol | Published : 2003


There has been controversy over the possible lymphoid origin of certain dendritic cell (DC) subtypes. To resolve this issue, DC and plasmacytoid pre-DC isolated from normal mouse tissues were analyzed for transient (mRNA) and permanent (DNA rearrangement) markers of early stages of lymphoid development. About 27% of the DNA of CD8(+) DC from thymus, and 22-35% of the DNA of plasmacytoid pre-DC from spleen and thymus, was found to contain IgH gene D-J rearrangements, compared with 40% for T cells. However, the DC DNA did not contain IgH gene V-D-J rearrangements nor T cell Ag receptor beta gene D-J rearrangements. The same DC lineage populations containing IgH D-J rearrangements expressed mRN..

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University of Melbourne Researchers