Journal article
High-avidity IgA protects the intestine by enchaining growing bacteria
Kathrin Moor, Mederic Diard, Mikael E Sellin, Boas Felmy, Sandra Y Wotzka, Albulena Toska, Erik Bakkeren, Markus Arnoldini, Florence Bansept, Alma Dal Co, Tom Voller, Andrea Minola, Blanca Fernandez-Rodriguez, Gloria Agatic, Sonia Barbieri, Luca Piccoli, Costanza Casiraghi, Davide Corti, Antonio Lanzavecchia, Roland R Regoes Show all
NATURE | NATURE PUBLISHING GROUP | Published : 2017
DOI: 10.1038/nature22058
Abstract
Vaccine-induced high-avidity IgA can protect against bacterial enteropathogens by directly neutralizing virulence factors or by poorly defined mechanisms that physically impede bacterial interactions with the gut tissues ('immune exclusion'). IgA-mediated cross-linking clumps bacteria in the gut lumen and is critical for protection against infection by non-typhoidal Salmonella enterica subspecies enterica serovar Typhimurium (S. Typhimurium). However, classical agglutination, which was thought to drive this process, is efficient only at high pathogen densities (≥108 non-motile bacteria per gram). In typical infections, much lower densities (100-107 colony-forming units per gram) of rapidly d..
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Awarded by Swiss National Science Foundation (SNF)
Awarded by SNF
Awarded by ETH Zurich
Awarded by Gordon and Betty Moore Foundation Marine Microbial Initiative Award
Awarded by Swiss National Science Foundation
Awarded by Deutsche Forschungsgemeinschaft
Awarded by Swedish Research Council
Funding Acknowledgements
The authors would like to acknowledge the support of ScopeM (ETHZ), and the staff at the RCHCI and EPIC animal facilities. They would also like to thank members of the Hardt and Hapfelmeier groups, as well as A. J. Macpherson, S. Sunagawa, M. F. Freeman, C. Mueller, B. Stecher, K. Endt, M. Stecher, M. Bajagic and M. Ackermann for technical help and/or their comments on the manuscript. E.S. is supported by the Swiss National Science Foundation (SNF, Marie Heim-Voglin award PMPDP3_158364 and Ambizione award PZ00P3_136742 to E.S.). W.-D.H. is supported by the SNF (310030_53074; Sinergia CRSII_154414/1), ETH Zurich (ETH-33 12-2) and the Novartis Freenovation Programme. D.R.B. acknowledges support from a Human Frontier Science Program Cross-Disciplinary Fellowship. E.B. is supported by the Excellence Scholarship and Opportunity Programme (ETH). R.S. acknowledges support from a Gordon and Betty Moore Foundation Marine Microbial Initiative Award (GBMF 3783). R.R.R. acknowledges support from the Swiss National Science Foundation (31003A_149769). T.V. is supported by a Deutsche Forschungsgemeinschaft postdoctoral fellowship (grant VO 2273/1-1) and M.E.S. by the Swedish Research Council (grants 2012-262 and 2015-00635).