Population pharmacokinetics of piperaquine in adults and children with uncomplicated falciparum or vivax malaria.
Te-Yu Hung, Timothy ME Davis, Kenneth F Ilett, Harin Karunajeewa, Sean Hewitt, Mey Bouth Denis, Chiv Lim, Doung Socheat
Br J Clin Pharmacol | Published : 2004
AIMS: To study the population pharmacokinetics of piperaquine after co-administration with dihydroartemisinin in uncomplicated malaria. METHODS: The disposition of piperaquine was studied in 85 Cambodian patients with uncomplicated falciparum or vivax malaria treated with the piperaquine-dihydroartemisinin coformulation Artekin. All patients were given Artekin orally at 0, 6, 24 and 32 h with a total piperaquine dose of 32-35 mg base kg-1. Adults were given tablets while children received either tablets or a dispersible granule formulation. Patients underwent either intensive (17-19 samples) or sparse (2-5 samples) blood sampling schedules over 35 days and clinical/parasitological follow-up ..View full abstract