In vitro interactions between piperaquine, dihydroartemisinin, and other conventional and novel antimalarial drugs.
Timothy ME Davis, Juliana Hamzah, Kenneth F Ilett, Harin A Karunajeewa, John C Reeder, Kevin T Batty, Sara Hackett, P Hugh R Barrett
Antimicrob Agents Chemother | Published : 2006
In an in vitro assessment of antimalarial combinations, dihydroartemisinin (DHA) showed no interaction or was mildly antagonistic when combined with piperaquine, pyronaridine, or naphthoquine. Interactions between 4-aminoquinolines and related drugs were also indifferent/antagonistic. The clinical significance of mildly antagonistic DHA combinations is uncertain but may become important if parasite drug sensitivity declines.