Artesunate suppositories versus intramuscular artemether for treatment of severe malaria in children in Papua New Guinea.
Harin A Karunajeewa, John Reeder, Kerry Lorry, Elizah Dabod, Juliana Hamzah, Madhu Page-Sharp, Gregory M Chiswell, Kenneth F Ilett, Timothy ME Davis
Antimicrob Agents Chemother | Published : 2006
Drug treatment of severe malaria must be rapidly effective. Suppositories may be valuable for childhood malaria when circumstances prevent oral or parenteral therapy. We compared artesunate suppositories (n = 41; 8 to 16 mg/kg of body weight at 0 and 12 h and then daily) with intramuscular (i.m.) artemether (n = 38; 3.2 mg/kg at 0 h and then 1.6 mg/kg daily) in an open-label, randomized trial with children with severe Plasmodium falciparum malaria in Papua New Guinea (PNG). Parasite density and temperature were measured every 6 h for > or = 72 h. Primary endpoints included times to 50% and 90% parasite clearance (PCT50 and PCT90) and the time to per os status. In a subset of 29 patients, pla..View full abstract