Journal article

Asymmetric dimethylarginine correlates with measures of disease severity, major adverse cardiovascular events and all-cause mortality in patients with peripheral arterial disease

Andrew M Wilson, David S Shin, Carlton Weatherby, Randall K Harada, Martin K Ng, Nandini Nair, Jan Kielstein, John P Cooke

VASCULAR MEDICINE | SAGE PUBLICATIONS LTD | Published : 2010

Abstract

Peripheral arterial disease (PAD) is associated with major cardiovascular morbidity and mortality. Abnormalities in nitric oxide metabolism due to excess of the NO synthase inhibitor asymmetric dimethylarginine (ADMA) may be pathogenic in PAD. We explored the association between ADMA levels and markers of atherosclerosis, function, and prognosis. A total of 133 patients with symptomatic PAD were enrolled. Ankle-brachial index (ABI), walking time, vascular function measures (arterial compliance and flow-mediated vasodilatation) and plasma ADMA level were assessed for each patient at baseline. ADMA correlated inversely with ABI (r = -0.238, p = 0.003) and walking time (r = -0.255, p = 0.001), ..

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Grants

Awarded by National Institutes of Health


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Funding Acknowledgements

This study was supported by grants from the National Institutes of Health (RO1 HL-75774, R21 HL085743, and K12 HL087746), and by the NIH Clinical and Translational Science Award. Dr Cooke is the inventor of patents owned by Stanford University for diagnostic and therapeutic applications of the NOS pathway from which he receives royalties.