Journal article

The Effect of Angiotensin-Converting Enzyme Inhibitors and Statins on the Progression of Aortic Sclerosis and Mortality

Reza Ardehali, Nicholas J Leeper, Andrew M Wilson, Paul A Heidenreich

JOURNAL OF HEART VALVE DISEASE | I C R PUBLISHERS | Published : 2012

Abstract

BACKGROUND AND AIM OF THE STUDY: Although aortic sclerosis has been associated with an increase in adverse cardiovascular outcomes, no proven therapy has been shown to slow its progression to overt aortic stenosis (AS). Thus, the hypothesis was assessed that treatment with angiotensin-converting enzyme inhibitors (ACE-Is), angiotensin receptor blockers (ARBs) or statins may be associated with an improvement in the clinical outcome of these patients. METHODS: A total of 4,105 patients with evidence of aortic sclerosis seen on transthoracic echocardiography (defined as thickening or calcification with a mean valve gradient < or = 15 mmHg) was identified. Patients with a sclerotic valve who wer..

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