Journal article

The Parahox gene Pdx1 is required to maintain positional identity in the adult foregut

Andrew M Holland, Sonia Garcia, Gaetano Naselli, Raymond J Macdonald, Leonard C Harrison

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY | U B C PRESS | Published : 2013

Abstract

The homeobox gene Pdx1 is a key regulator of pancreas and foregut development. Loss of Pdx1 expression results in pancreas agenesis and impaired development of the gastro-duodenal domain including Brunner’s glands. We previously demonstrated a key role for Pdx1 in maintaining the integrity and function of insulin-secreting beta cells in the adult pancreas. In the present study, we aimed to determine if expression of Pdx1 is required to maintain the cellular identity of the gastro-duodenal domain in adult mice. Immunohistological studies were performed in a mouse model in which expression of Pdx1 was conditionally repressed with the doxycycline-responsive tetracycline transactivator system. M..

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University of Melbourne Researchers