Journal article
Transcriptome of pancreas-specific Bmpr1a-deleted islets links to TPH1-5-HT axis
FX Jiang, Y Mishina, A Baten, G Morahan, LC Harrison
Biology Open | COMPANY OF BIOLOGISTS LTD | Published : 2015
DOI: 10.1242/bio.011858
Abstract
Bone morphogenetic protein (BMP) signaling is crucial for the development and function of numerous organs, but its role on the function of pancreatic islets is not completely clear. To explore this question, we applied the high throughput transcriptomic analyses on the islets isolated from mice with a pancreas-specific deletion of the gene, Bmpr1a, encoding the type 1a BMP receptor. Consistently, these pBmpr1aKO mice had impaired glucose homeostasis at 3 months, and were more severely affected at 12 months of age. These had lower fasting blood insulin concentrations, with reduced expression of several key regulators of β-cell function. Importantly, transcriptomic profiling of 3-month pBmpr1a..
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Awarded by National Institutes of Health
Funding Acknowledgements
This study was supported by a Partnership Program Grant from the Juvenile Diabetes Research Foundation and the National Health and Medical Research Council of Australia, by Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIIS (to L.C.H.), by grants from Juvenile Diabetes Research Foundation (4-2006-1025), Diabetes Australia Research Trust, Diabetes Research Foundation of Western Australia and Medical Research Foundation of Royal Perth Hospital (to F.-X.J.) and, in part, by the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences (ES071003-11 to Y.M.).